HECTD2 and neoplasm: Accordingly, despite the recruitment of immune cells in the HCmel31.Hectd tumours, their growth was unaffected by an adaptive immune response, as comparably accelerated growth of HCmel31.Hectd cells were observed also in severely immunodeficient Rag1−/−Il2rg−/−Cd47−/− recipients, lacking all lymphocytes (Fig. S9), demonstrating a tumour cell-intrinsic effect of HECTD2 expression.