In agreement with the differential effects on growth or in vivo immune infiltration of the three murine cell lines, a further expression of HECTD2 did not affect transcription of these immune mediators in BrafV600E cells and only moderately increase Ccl5 and Cxcl10 transcription in B16 cells (Fig. 6b, c), again illustrating the different melanoma profiles exemplified by these three cell lines. This evidence concerns the gene CCL5 and melanoma.