BRAF and melanoma: Despite the sporadic somatic nature of the disease, one-third of cases have a first or second degree family history of CMN in the largest published cohort,5,6 suggesting germline susceptibility to NRAS/BRAF somatic pathogenic variant in affected families, including the already established variants in MC1R.6 We hypothesized that new predisposing copy-number variants found via this rare disorder could also predispose to melanoma in the normal population.