Interestingly, however, our data demonstrate clearly that increased PPP2R3B expression correlates with improved disease-specific survival in melanoma, mirroring the significant protective effect of PPP2R3B expression in urothelial cancer and pancreatic cancer data sets from the TCGA database.37 A significant association between expression and survival is not seen in the smaller melanoma TCGA data set; however, this may be due to lack of statistical correction for known associated factors. Here, PPP2R3B is linked to familial pancreatic carcinoma.