ESR1 and hepatocellular carcinoma: Next, we identified the differentially expressed genes (DEGs) between the ESR1-H and ESR1-L HCC groups as the ESR1 signatures “Sig ESR1-L” (n = 482) and “Sig ESR1-H” (n = 785) (p < 10–6, permutation t-test with fold change [FC] >0.5; Supplementary Table S4).