The ESR1-L group exhibited enrichment of the aggressive prognostic classifiers such as iCluster1 in TCGA subtype, S1 and S2 in Hoshida’s classification, G1 and G3 in Boyault’s classification, and UP in liver cancer stem cell features (p < 0.001, chi-square test); in contrast, the ESR1-H group was enriched in the less aggressive prognostic classifiers, such as S3 in Hoshida’s classification, G5 and G6 in Boyault’s classification, and DOWN in liver cancer stem cell features (p < 0.001, chi-square test, Fig. 2b). Here, ESR1 is linked to liver cancer.