The first region in the chromosome (CHR) 2, positioned between 26.8 and 28.6 Mbp, contains the SNPs with the lowest p values and harbors three important MetS-related genes: GCKR, C2orf16, and ZNF512. Many of the genes in Table 3 were already reported in associations with up to four metabolic traits, [24] but there are also seven regions that, according to the NHGRI-EBI catalog of human GWA studies (GWAS catalog; https://www.ebi.ac.uk/gwas/), do not contain SNPs reported in association with MetS. The gene discussed is SPATA31H1; the disease is metabolic syndrome.