While these genes have not been directly related to MetS, some have been implicated with other MetS-related traits and behaviors such as SBP (gene MAP4 [36]), alcohol dependence, and gout (gene ADH1B [37]), rheumatoid arthritis, systemic sclerosis, and the immune response to smallpox vaccine (gene BLK), and neuronal processes and the risk of acute atherothrombotic stroke (gene SEMA7A [38]). The gene discussed is BLK; the disease is systemic sclerosis.