The BRCA2 mutant case and the four other cases showing HRD-like SNV and indel patterns also showed the presence of the rearrangement signatures associated with BRCA1/2 deficiency, although to a lesser extent than that seen in TCGA-64-1680 and in BRCA1/2 mutant breast cancer in general. The gene discussed is BRCA2; the disease is breast carcinoma.