BRCA2 and breast cancer: We calculated the breast cancer trained HRDetect values for all WGS cases by standardizing the lung predictors combined with the original breast cancer dataset, and found that the two above described, likely BRCA2 deficient LUSC cases; TCGA-66-2766 and TCGA-21-5782 have the highest HRDetect values, the former of which even exceeded 0.7, which was proposed to be the threshold value for bona fide HR deficient cases in breast cancer (Supplementary Fig. 12).