Genome-wide association studies (GWAS) have identified several single nucleotide polymorphisms (SNPs) present at the ITLN1 locus as risk alleles for Crohn’s disease, a main subtype of IBD, which is characterized by dysbiosis, epithelial barrier dysfunction, and immune function perturbations; processes consistent with an innate immune dysfunction1,23–28. The gene discussed is ITLN1; the disease is Crohn disease.