Although multiple GWAS have identified ITLN1 SNPs in Crohn’s disease, the calculated OR(s) noted above are modest compared to variants of nucleotide-binding oligomerization domain-containing protein 2 (NOD2/CARD15): rs2066847 (frameshift variant L1007fsX1008: OR = 3.99; CI = NR) and interleukin 23 receptor (IL23R): rs11465804 (intron variant T/G: OR = 1.38—2.56)1,48–50. Here, NOD2 is linked to Crohn disease.