We also observed a non-significant trend of increased Rab10 phosphorylation in PBMCs from sporadic PD patients, and additional analysis of LRRK2 activity is warranted in larger cohorts and across broader populations to better understand the range of increase in kinase activity conferred by other pathogenic LRRK2 variants or in sporadic PD more broadly. Here, RAB10 is linked to Parkinson disease.