In the multivariable analysis, age (HR 1.158; 95% CI 1.050–1.278; P = 0.003), CRP level (HR 1.212; 95% CI 1.004–1.462; P = 0.045), FVC (HR 0.902; 95% CI 0.839–0.969; P = 0.005), and a UIP pattern on HRCT (UIP to non-UIP, HR 4.580; 95% CI 1.167–17.975; P = 0.029) were independently associated with survival. The gene discussed is CRP; the disease is idiopathic pulmonary fibrosis.