Indeed, we found that PLANE-mediated suppression of NCOR2 expression was due to selective repression of AS production of the NCOR2-202 transcript that encodes one of the major NCOR2 protein isoforms, NCOR2 isoform 236, demonstrating a tumour suppressive function of this isoform. The gene discussed is MELTF-AS1; the disease is neoplasm.