MELTF-AS1 and cancer: Nonetheless, similar to the pan-cancer upregulation of PLANE in tissue samples, all the cancer cell lines examined expressed higher levels of PLANE than the CCC-HSF-1 normal skin fibroblast cell line irrespective of their amplification status (Supplementary Fig. 2e), suggesting that additional causal mechanisms such as transcriptional regulation are involved in the upregulation of PLANE in cancer cells.