I.t. SAP treatment resulted in a 23-fold reduction of lung CFU 16 h after infection (median 2.3 × 104, IQR 1.1 × 105−1.0 × 105 vs. 5.3 × 106, IQR 9.5 × 106−7.7 × 106; P = 0.008) (Fig. 6d). This evidence concerns the gene APCS and infection.