CDH1 and breast cancer: However, the continuous repression of E-cadherin in one of the three tumor cell lines (line 2) in the absence of oncogenic KRAS, SLUG, or SNAIL implies that, despite significant increases in ITGB3 and GATA3, the maintenance of mesenchymal characteristics of claudin-low mammary cancer cells is multifactorial and can also be controlled by other molecular mechanisms.