CD40LG and atherosclerosis: As we did not see alterations in the suppressive capacities of CD40L-deficient Tregs decrease in vitro, we assume that the decrease in Th1 response in our T cell-specific CD40L (Cd40lfl/fl/Cd4Cretg) deficient mice with advanced atherosclerosis affects atherogenesis to a larger extent than the decrease in, potentially partly dysfunctional, Tregs.