APOE and atherosclerosis: To explore the effect of CD40L in T cells and platelets in atherosclerosis, we generated mice with a T cell-specific (referred to as Cd40lfl/fl/Cd4Cretg) or platelet-specific deletion of CD40L (referred to as Cd40lfl/fl/Pf4Cretg) and backcrossed them to Apoe−/− mice to induce atherosclerosis (Supplementary Fig. 1a).