PLCG1 and Behcet disease: Specific genes in this pathway and hit by a deleterious gDNM in BD include PDGFB, a platelet-derived growth factor gene responsible for idiopathic basal ganglia calcification56 that frequently accompanies psychiatric symptoms such as mood instability57, and PLCG1, encoding phospholipase C gamma 1 whose forebrain-specific disruption causes mania-like behavior in mice58.