We conclude that this is unlikely the case, while we cannot completely exclude this possibility as we could not access the DNA samples from non-hematopoietic cells of the BD probands with a deleterious pzDNM in SRCAP. The SRCAP gene is highly intolerant to LoF variants in the general population (pLI > 0.99) and known as a gene responsible for Floating–Harbor syndrome47, which is characterized by ID, short stature, expressive-language delay, and distinctive facial appearance. Here, SRCAP is linked to Behcet disease.