In particular, we observed that deleterious gDNMs in XKR6 (2 LoF and 9 damaging missense gDNMs) are exome-wide significantly enriched in the combined group of BD, schizophrenia, ASD, and DD (Table 1, P = 2.24 × 10−6, one-tailed Poisson test), indicating a strong association of XKR6 with a broad spectrum of neuropsychiatric/developmental disorders. This evidence concerns the gene XKR6 and Behcet disease.