Among them, we observed exome-wide significant enrichment of LoF gDNMs in KMT2C, a gene encoding a histone methyltransferase protein, in the combined group of neuropsychiatric/developmental disorders (P = 2.48 × 10−7 for BD + schizophrenia + ASD, and P = 3.03 × 10−16 for BD + schizophrenia + ASD + DD, one-tailed Poisson test). The gene discussed is PRDM9; the disease is schizophrenia.