Although very different results have been presented in the literature with the expression of MCM complex subunits in cancer patients, most of them have shown that MCM complex subunits have an effect on cell proliferation, invasion and metastasis.19, 20 Liu et al. showed an increase in tumor size and the number of metastatic lymph nodes, progression in the tumor TNM stage, and an increase in tumor invasion rates with MCM2 overexpression in patients with bladder cancer.21 This evidence concerns the gene MCM2 and cancer.