According to univariate analyses, AJCC stage (stage I–III vs. Stage IV : p = 0.01), histopathological subgrups (keratinizing vs. non-keratinizing vs. basaloid; p = 0.02), tumor response after treatment (complete response vs. non-complete response : p = 0.03), MCM3 expression (low vs. high; p = 0.04), MCM5 expression (low vs. high; p = 0.01), and MCM7 expression (low vs. high; p ≤ 0.0001) were the prognostic factors that predict PFS. The gene discussed is MCM3; the disease is neoplasm.