GSN and oral cavity cancer: Gelsolin upregulation and an adverse effect on prognosis have been reported in lung, prostate, and oral cavity cancers;9, 10, 11 however, decreased expression of gelsolin suggests a tumor-suppressing role in breast and colon malignancies.12, 13 Regarding the effects of gelsolin on carcinogenesis, currently no studies exists on the expression of gelsolin in LSCC tissues and its impact on prognosis.