Various studies reported that increased motility functions of cells are related to higher rates of tumor invasion and reduced survival time.26, 27 In some animal models, the motility regulating role of gelsolin has been observed.28, 29 In 229 patients with lung carcinoma, Shieh et al. (1999) found a strong inverse relationship between the level of gelsolin expression and survival. This evidence concerns the gene GSN and lung carcinoma.