A recent study focused on the pathophysiological nature of the common ABCG2 gout and hyperuricemia-associated variant Q141K (rs2231142) and found that participants with the Q141K ABCG2 variant displayed elevated serum urate, unaltered fractional excretion of uric acid (FEUA), and significant evidence of reduced extrarenal urate excretion. The gene discussed is ABCG2; the disease is gout.