ABCG2 and hyperuricemia: More interestingly, Hoque et al. revealed that in female Q140K+/+ mice (humanized for Q141K), there was no hyperuricemia, while male Q140K+/+ mice showed hyperuricemia and impaired renal and intestinal urate excretion, and they believed that this was related to the difference in the abundance of ABCG2 in the kidneys and intestines between male and female mice.