P2RY12 and status epilepticus: The first demonstration of a role for P2YRs during status epilepticus stems from a study using the intraperitoneal KA-induced status epilepticus mouse model demonstrating that P2Y12R deficiency leads to a suppression of microglial morphological changes associated with status epilepticus and in an exacerbated seizure phenotype (Eyo et al. 2014; Avignone et al. 2015).