Using the intra-amygdala KA mouse model, Alves et al. (Alves et al. 2017) showed that, in contrast to status epilepticus, hippocampal P2YR transcription and expression is either increased (mRNA: P2ry1, P2ry2 and P2ry6; protein: P2Y1R, P2Y2R and P2Y12R) or remains unchanged during epilepsy, suggesting hippocampal P2YR upregulation to be the predominant response during experimental epilepsy. This evidence concerns the gene P2RY6 and epilepsy.