The P2X2R has been shown to be downregulated 24 h following status epilepticus in the intra-amygdala KA mouse model (Engel et al., 2012), while P2X4R expression was found to be increased in the hippocampus of mice 24 h following systemic administration of KA (Avignone et al. 2008; Ulmann et al. 2013), but not intra-amygdala KA- or pilocarpine-induced status epilepticus (Dona et al. 2009; Engel et al. 2012). Here, P2RX4 is linked to status epilepticus.