Following intra-amygdala KA induced status epilepticus in mice, P2X7R transcription seems to be under the control of the specificity protein 1 (Sp1) (Engel et al. 2017) which is a member of the injury-activated transcription factor (IATF) family and highly expressed in the brain (Kiryu-Seo et al. 2008). The gene discussed is SP1; the disease is status epilepticus.