Analyzing the hippocampus at different time-points following status epilepticus, the authors found that while mRNA levels of the uridine-sensitive P2Y2R, P2Y4R and P2Y6R were increased, transcription of the adenine-sensitive P2Y1R, P2Y12R and P2Y13R was downregulated. Here, P2RY12 is linked to status epilepticus.