GPR17 and metabolic disease: Whereas a subset of the GPR17 variants were exclusively observed in control cohorts (R4W, G91R, D156Y, R344M, and S362G), most variants were detected in both control and metabolic disease cohorts (F43L, V109M, R133C, R263H, V285I), or exclusively in the metabolic disease cohorts (V96M, V103M, D105N, A131T, G136S, R248Q, R301H, G354V).