PROS1 and bacterial vaginosis: The functional categories in the CVM of women with BV included transporters, transcriptional factors, sporulation, fructose and mannose metabolism, porphyrin metabolism, phosphotransferase system, etc. In the CVM of women without BV, these comprised energy metabolism, membrane and intracellular structural proteins, lipopolysaccharide (LPS) biosynthesis, other glycan degradation, citrate cycle, and pore ion channels.