For CREB5, 99.26% C-A peoples had negative effect, but 88.46% of A-A individuals had positive effects.Remarkably, incidence and death rate of cancer is highest in African-American ethnic group [43] (S9 Table), whereas one of the causes of higher incidence and death rate may be due to the large frequency of positive effect alleles of CREB5 and LMNTD1 genes in this ethnic group (S7 Table). Here, CREB5 is linked to cancer.