NR3C2 and Hypertension: Moreover, this biochemical pattern can also be seen with suppressed aldosterone in disorders mimicking aldosterone activity, including Liddle syndrome (due to gain-of-function variants in ENaC) or activation of the mineralocorticoid receptor by other steroid hormones, such as progesterone in pregnancy-associated hypertension (due to a variant that enhances sensitivity of the mineralocorticoid receptor to progesterone) or cortisol as in Apparent Mineralocorticoid Excess (due to loss of protection of the mineralocorticoid receptor from cortisol by the enzyme HSD11B2) [16].