Recently, researchers found that GBP2 was highly expressed in PC and positively correlated with the expression of immune checkpoints (e.g., PDCD1, PDCD1-L1, CTLA4 etc.)Patients with PC and high expression of GBP2 were linked to a poor prognosis and an AUC of 0.69 for 3-year survival [28]. The gene discussed is CTLA4; the disease is pachyonychia congenita.