Ability of multidrug resistant CCM to bind to homotypic cell membranes and the integrin-associated protein CD47 on CCM endows CCM/CS/R-D with an excellent targeting ability and in vivo escape ability, which are conducive to the efficient arrival and function of DOX and siRNA in tumors (Zhao et al., 2020). Here, CD47 is linked to cerebral cavernous malformation.