We and others have shown that the loss of LKB1 directly leads to CRTC activation and extensive, elevated CRTC1-CREB-mediated transcription in human lung cancer cells and primary tumors (Yang et al., 2019; Chen et al., 2016; Cao et al., 2015; Hollstein et al., 2019; Murray et al., 2019; Rodón et al., 2019). The gene discussed is STK11; the disease is lung carcinoma.