The CRTC family consists of three members, CRTC1, CRTC2, and CRTC3, which play important roles in metabolism, aging, and cancer (Altarejos and Montminy, 2011; Iourgenko et al., 2003; Conkright et al., 2003; Tonon et al., 2003). This evidence concerns the gene CRTC2 and cancer.