CRTC1 and mucoepidermoid carcinoma: We initially identified CRTC1 as a fusion partner with the Notch transcriptional co-activator MAML2, due to a t(11;19) chromosomal translocation in mucoepidermoid carcinoma (MEC), the most common salivary gland malignancies and lung tumors (Tonon et al., 2003).