Lung cancer with LKB1 deficiency exhibits resistance to chemotherapy, targeted therapeutics and especially to immune checkpoint inhibitors in preclinical models and/or human patients (Chen et al., 2012; Carretero et al., 2010; Han et al., 2014; Skoulidis et al., 2018; Schabath et al., 2016; Rizvi et al., 2018). This evidence concerns the gene STK11 and lung carcinoma.