PTGS2 and cancer: In our previous studies, we also showed that LKB1-deficiency led to CRTC activation of many CREB-dependent genes, including NR4A2, PTGS2 (aka COX-2), LYPD3, INSL4, and LINC00473, which play important roles in cancer cell growth, survival or invasive properties (Chen et al., 2016; Cao et al., 2015; Gu et al., 2012; Komiya et al., 2010).