To assess the individual functional contributions of the three CRTC family members in lung malignancies, we first evaluated their expression patterns by quantitative RT-PCR (RT-qPCR) and western blot analyses of SV40-transformed, non-tumorigenic human bronchial epithelial cells (BEAS-2B), 7 LKB1-wt and 6 LKB1-null NSCLC cell lines. Here, CALR is linked to non-small cell lung carcinoma.