SIK1 and neoplasm: This notion is further supported by recent CRISPR/Cas9-mediated gene editing studies revealing that knock-outs of SIK1 and SIK3, but not of other AMPK family members, increased tumor growth in a mouse model of oncogenic KRAS-driven lung adenocarcinoma (Hollstein et al., 2019; Murray et al., 2019).