To identify key signaling pathway(s) impacted by LKB1 inactivation in lung cancer, we previously performed an unbiased global gene expression profiling analysis and discovered that multiple cAMP/CREB-regulated targets, such as LINC00473, INSL4, NR4A1-3, and PTGS2, were highly expressed in human LKB1-null lung cancer cell lines and primary tumors (Yang et al., 2019; Chen et al., 2016). This evidence concerns the gene PTGS2 and lung cancer.