TFF3,TFF3 homodimer, and TFF37-54 all reducedapoptosis of SH-SY5Y, a human neuroblastoma cell line (Figures 3 and 4), aligning well with reported antiapoptotic activity, includingcerebral ischemia.22,33,72,73 These antiapoptotic effects support TFF3’s(neuro)protective role,1,33,72,73 as well as its association as a tumor growthpromoter in different cancers.8,74,75 TFF3 and its homodimer did not display any cytotoxic or hemolyticeffects, an important aspect for future therapeutic development ofTFF3. This evidence concerns the gene TFF3 and neoplasm.