Most common EB‐causing gene variants, such as KRT5, KRT14, LAMA3, LAMB3, LAMC2 and Col7A1, are also expressed in lymphoid organs,12, 15, 16 suggesting that dysfunction of these gene products could also affect the immune system and that EB patients may have a systemic immunity defect. This evidence concerns the gene COL7A1 and epidermolysis bullosa.