Moreover, lower SPISE index significantly correlated in adults or adolescents with the presence of T2D [36], metabolic syndrome [37, 39], risk of cardiovascular diseases [36], non-alcoholic fatty liver disease (NAFLD)[38], abdominal obesity, higher levels of C-reactive protein (CRP) and lower levels of adiponectin[24]. The gene discussed is ADIPOQ; the disease is type 2 diabetes mellitus.