This contrasts with a study where GCV treatment of Ldlr−/−/p16-3MR mice reduced SAβG+ cells, atherosclerosis extent, expression of inflammatory cytokines (IL1α, TNFα, MCP-1, MMPs 3, 12 and 13), and p16.5 This study concluded that GCV reduced atherosclerosis by removing senescent cells,5 although detection and removal of SAβG+ cells in fatty streaks within 9 days of fat feeding suggests these cells may represent newly migrated macrophages, not senescent cells. This evidence concerns the gene CDKN2A and atherosclerosis.