ASPM is a positive regulator of the canonical Wnt/β-catenin signaling (Major et al., 2008; Hsu et al., 2019) and thus promotes cancer stemness and progression in prostate cancer (Pai et al., 2019) and hepatocellular carcinoma (Liao et al., 2020). This evidence concerns the gene ASPM and hepatocellular carcinoma.