We are among the first to report that (1) both ASPM and microcephalin (MCPH1) are centrosomal/spindle proteins (Zhong et al., 2005, 2006); (2) both proteins functionally associate with breast cancer type 1 susceptibility protein BRCA1 (Xu et al., 2004; Zhong et al., 2005); (3) MCPH1 plays an important role in DNA damage-induced cellular responses (Xu et al., 2004). Here, BRCA1 is linked to cancer.