Using paired-end DNA sequencing, Ng et al.[89] (2012) discovered an intronic deletion polymorphism in BIM that was sufficient to confer intrinsic resistance to the tyrosine kinase inhibitors, imatinib and gefitinib in chronic myeloid leukemia (CML) and epidermal growth factor receptor-mutated non-small-cell lung cancer (EGFR NSCLC). This evidence concerns the gene EGFR and non-small cell lung carcinoma.