Melatonin attenuates chronic pain–related MI susceptibility by inhibiting the RIP3-MLKL/CaMKII signaling pathway (Yang et al., 2018), and it can also alleviate endothelial necroptosis by the RIPK3-PGAM5-CypD-mPTP axis in cardiac microvascular I/R injury (Zhou et al., 2018). Here, RIPK3 is linked to myocardial infarction.