Interestingly, TFEB overexpression in mice in which autophagy was genetically suppressed by deletion of hepatic Atg7, did not preclude the development of or decrease fatty infiltration in hepatic steatosis, suggesting that the effects of TFEB on lipid metabolism require a functional autophagic pathway (Settembre et al., 2013). The gene discussed is ATG7; the disease is Hepatic steatosis.