It has been reported that both PTEN and PIK3R1 (also known as PI3K p85α), a regulatory subunit of PI3K, are capable of inactivating the PI3K/AKT signaling and inhibiting tumor progression (Luo et al., 2005; Taniguchi et al., 2010; Vallejo-Diaz et al., 2019; Kong et al., 2020; Coleman et al., 2021). The gene discussed is PIK3CA; the disease is neoplasm.