Figures 2I,J show the representative images of low-grade and high-grade tissues, respectively. The patients with low-grade tumor in our cohort have higher expression of TLR4 than the patients with high-grade tumor (P = 0.0029, Figure 2K). Figures 2L,M show the representative images of MIBC and NMIBC, respectively. The patients with NMIBC have higher expression of TLR4 than the patients with MIBC (P = 0.0002, Figure 2N). This evidence concerns the gene TLR4 and neoplasm.