The genotype-phenotype correlation of the PHEX gene mutation in XLH has not been well established, and scholars have followed genotype-phenotype correlation research with great interest, particularly regarding the relationship between phenotype and mutation type or location (Holm et al., 2001; Cho et al., 2005; Rafaelsen et al., 2016; Zhang et al., 2019; Zheng et al., 2020). This evidence concerns the gene PHEX and X-linked hypophosphatemia.