In addition to lung cancer, also in other tumor types it is possible to achieve a radiosensitizing effect by blocking the increase in NRF2 activity: the restoration of the sensitivity to IR in nasopharyngeal carcinoma cells is associated with the inhibition of NRF2 pathways and the increase in ROS generation by Salinomycin (159). The gene discussed is NFE2L2; the disease is lung cancer.