Surprisingly, in lung cancer, NRF2 was correlated not only with the induction of some “canonical” target genes (Figure 4D), such as HO-1, NOQ-1 and Glutamate-Cysteine Ligase Catalytic subunit (GCLC), but also with some “non-canonical” ones like NOTCH1 (178). This evidence concerns the gene GCLC and lung cancer.