In the TME, IL6 also regulates immune cell transformation from monocytes to a suppressive M2 phenotype, thereby promoting the proliferation and metastasis of various cancers, including lung (29), breast (30), hepatocellular (31), prostate (32), colorectal (33), renal cell (34), cervical (35), and ovarian cancers (36). The gene discussed is IL6; the disease is ovarian carcinoma.