ALPL might restrict the function of the WNT5A–FZD2–STAT3 axis, a non-canonical WNT pathway promoting epithelial-mesenchymal transition progression, which results in attenuated migration and invasion in high grade serous ovarian cancer cells and improves survival in patients with serous ovarian cancer (52). The gene discussed is STAT3; the disease is ovarian serous adenocarcinoma.