The results showed that the fraction of naive B cells (p = 0.001), memory B cells (p < 0.001), plasma cells (p = 0.005), CD8 T cells (p = 0.002), resting memory CD4 T cells (p = 0.023), regulatory T cells (Tregs) (p = 0.019), M0 macrophages (p < 0.001), M1 macrophages (p = 0.017), M2 macrophages (p = 0.001), resting dendritic cells (p = 0.002), resting mast cells (p < 0.001), and activated mast cells (p < 0.001) were significantly different between the thyroid carcinoma group and normal thyroid group. Here, CD8A is linked to thyroid gland disorder.