This synonymous SNP (sSNP) located in the first exon of the gene is associated with dietary macronutrient and alcohol intake preferences and various metabolic traits including hypertension and total body fat.[11, 12, 13] Studying FGF21 genotype–phenotype associations therefore provides a unique opportunity to study the basis of FGF21 resistance in people. This evidence concerns the gene FGF21 and hypertensive disorder.