Left ventricular diastolic dysfunction, elevated serum levels of N-terminal pro-B-type natriuretic peptide (NT-proBNP), hemoglobinuria, proteinuria, macro-albuminuria, chronic kidney disease (CKD), and coronary disease are all “biomarkers” that have been shown to help identify adult patients with SCD who are at a higher risk of morbidity and death [5]. The gene discussed is NPPB; the disease is chronic kidney disease.