TH and thyroid gland disorder: Therefore, experimental reduction of thyroid function with anti-thyroid substances better known as endocrine disruptors (substances like propylthiouracil, methimazole and thiourea) chemically blocks the synthesis of TH and causes a delay in larval development and metamorphosis (Gobdon, Goldsmith & Charipper, 1943; Degitz et al., 2005; Thambirajah et al., 2019).