Lebedev et al. (2019) demonstrated that the increased expression of NMU was associated with poor prognosis in neuroblastoma. Similarly, the oncogenic action of NTS has been described in different cancers with effects at each step of progression (Ouyang et al., 2017). For example, NTS promotes glioma cell invasiveness through NTSR1 in vitro and in vivo (Ouyang et al., 2015). Here, NTSR1 is linked to central nervous system cancer.