The datasets analyzed for this work are available from public databases: The Cancer Genome Atlas (TCGA) from UCSC Xena (GDC TCGA Colon Cancer (COAD)), The Open Targets Platform (20 diseases associated with BCL2L1, 97 diseases associated with TYMS), The cBio Cancer Genomics Portal (Colorectal Adenocarcinoma (TCGA, PanCancer Atlas)), The Human Protein Atlas (THPA) (ENSG00000176890-TYMS; ENSG00000171552-BCL2L1), GeneMANIA (https://genemania.org/search/homo-sapiens/TYMS/BCL2L1/), the LinkedOmics database and the Gene Expression Omnibus (GEO) (GSE12945 and GSE89076). Here, TYMS is linked to malignant colon neoplasm.