TP53 and colorectal cancer: KEGG pathway results found that apoptosis (P = 6.58E−18), apoptosis-multiple species (P = 1.14E−15), colorectal cancer (P = 5.96E−14), Platinum drug resistance (P = 1.39E−12) and p53 signaling pathway (P = 1.09E−10) were five significantly enriched pathways (Fig. 7D).