We used the transcriptome sequencing data of 371 lncRNAs, 371 mRNAs, and 367 miRNAs of HCC tumor tissue and adjacent normal tissue from The Cancer Genome Atlas (TCGA) platform to identify key differentially expressed (DE) RNAs, and we constructed an associated Myc ceRNA network to reveal the underlying mechanism in HCC carcinogenesis. This evidence concerns the gene MYC and hepatocellular carcinoma.