We found significant interactions between age and genetic risk for severe COVID‐19 on levels of placental growth factor, PlGF [β = −0.020 (−0.031, −0.009), P = 0.0003, PFDR = 0.009, R2 = 0.022], TNF‐α [β = −0.014 (−0.024, −0.004), P = 0.004, PFDR = 0.070, R2 = 0.007], SAA [β = −0.052 (−0.089, −0.015), P = 0.006, PFDR = 0.070, R2 = 0.014] and IL‐8 [β = −0.022 (−0.039, −0.006), P = 0.009, PFDR = 0.071, R2 = 0.017] (Figure 3 top). The gene discussed is TNF; the disease is COVID-19.