While other studies identified a potential involvement of STAT3 phosphorylation in IL-10 mediated suppression of Treg cells (35), we propose the involvement of the p38 MAPK signaling pathway, a well-known integrator of environmental stress that has previously been shown to be involved in T cell differentiation (36) and to be critical in models of MS (37). The gene discussed is STAT3; the disease is myeloid sarcoma.