Recently, a study with induced pluripotent stem cell-derived CD34+ cells from a PV patient showed that JAK2 V617F not only induces inflammation through IFNγ and NFκB pathways, but also protects from DNA damage due to inflammation via upregulation of dual-specificity phosphatase 1 (DUSP1) (98). Here, JAK2 is linked to acquired polycythemia vera.