Mouse homologs of MF-overproduced cytokines (except for IL-8/CXCL8, which does not have a direct homolog in mice) are overproduced in JAK2 V617F (or Jak2 V617F, if the mouse gene was mutated rather than the mutant human gene introduced) and MPL W515L MPN mouse models, and furthermore are also overproduced in non-mutant mouse cells co-transplanted with JAK2 or MPL mutant cells: a non-cell-autonomous induction directed by the malignant cells, in direct analogy to human MPNs (86). Here, MPL is linked to myeloproliferative disorder.