TNF and myeloid neoplasm: The duality of TNF as an endogenous factor, which could potentially be either myelosuppressive or myeloproliferative, has led to hypotheses that this cytokine could play a major role in myeloid neoplasms, in the manner of promoting clonal dominance by exerting a myelosuppressive role on benign hematopoiesis while simultaneously exerting a myeloproliferative role on malignant hematopoiesis.