Among cytokines surveyed by mass cytometry, a subset were identified that were inducible by TPO and TLR ligands, most of which were also inducible by TNF: these included TNF itself, IL-6, and IL-8/CXCL8, all previously implicated in MPN pathophysiology (48). This evidence concerns the gene CXCL8 and myeloproliferative neoplasm.