Other miRNAs upregulations in T2DM impacting the proinflammatory genes expression are: miR-146a decreasing the expression TNF receptor-associated factor 6 (TRAF6) and interleukin 1 receptor-associated kinase 1 (IRAK1); miR-200c family members increasing the expression of COX-2 and MCP-1; and miR-504 increasing the expression of IL-6, COX2 and MCP-1 (52). The gene discussed is PTGS2; the disease is type 2 diabetes mellitus.