INS and type 2 diabetes mellitus: Studies have reported an increased use of natural products in patients with T2DM (13–15); this is due to the long-term use of oral hypoglycemic agents and insulin, characterized by numerous side effects, that include episodes of hypoglycemia, gastrointestinal problems (nausea, vomiting and diarrhea), edema and even hepatorenal disorders (16, 17).