Anson et al. showed that C57BL/6 mice (susceptible to diet-induced obesity, diabetes mellitus, and atherosclerosis), maintained on an IF regimen consisting of fasting every other day, had improved insulin sensitivity (as evidenced by reduced serum glucose and insulin levels), increased BHB levels, and improved neuronal resistance to excitotoxicity, relative to mice on an ad libitum diet. The gene discussed is INS; the disease is diabetes mellitus.