The expression of the different pathogenic ALS mutations in SOD1 (Zhang et al., 1997; Williamson and Cleveland, 1999), TARDBP (Wang et al., 2013; Magrane et al., 2014), FUS, and C9orf72 (Baldwin et al., 2016) contributes to axonal transport defects, which are early pathology events that precedes neuronal loss and clinical symptoms. This evidence concerns the gene C9orf72 and amyotrophic lateral sclerosis.